Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes.

@article{Arun2013NeurofibrominIW,
  title={Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes.},
  author={Vedant Arun and Lionel Worrell and Joseph C Wiley and David R Kaplan and Abhijit Guha},
  journal={FEBS letters},
  year={2013},
  volume={587 10},
  pages={
          1466-73
        }
}
Neurofibromin (NF1) is encoded by the NF1 tumour suppressor gene. Mutations result in a disorder known as Neurofibromatosis Type 1 (NF-1), and patients are often diagnosed due to the presence of unusual pigmentary patterns that include Café au lait macules (CALMs). Little is known about how loss of NF1 results in pigmentary defects in melanocytes. We sought to identify novel NF1 interacting proteins and elucidate the molecular mechanisms underlying the pigmentary defects. The cytoplasmic Dynein… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-2 OF 2 CITATIONS

Pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1

  • GMS Interdisciplinary plastic and reconstructive surgery DGPW
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

In vitro modeling of hyperpigmentation associated to neurofibromatosis type 1 using melanocytes derived from human embryonic stem cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Direct observation of individual endogenous protein complexes in situ by proximity ligation

O Soderberg
  • Nat. Methods
  • 2006