Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium

@inproceedings{Bloomfield2015NeurofibrominCM,
  title={Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium},
  author={Gareth Bloomfield and David Traynor and Sophia P Sander and Douwe M Veltman and Justin A. Pachebat and Robert R Kay},
  booktitle={eLife},
  year={2015}
}
Cells use phagocytosis and macropinocytosis to internalise bulk material, which in phagotrophic organisms supplies the nutrients necessary for growth. Wildtype Dictyostelium amoebae feed on bacteria, but for decades laboratory work has relied on axenic mutants that can also grow on liquid media. We used forward genetics to identify the causative gene underlying this phenotype. This gene encodes the RasGAP Neurofibromin (NF1). Loss of NF1 enables axenic growth by increasing fluid uptake. Mutants… CONTINUE READING
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