Neurofibromin Regulates Seizure Attacks in the Rat Pilocarpine-Induced Model of Epilepsy

@article{Ren2015NeurofibrominRS,
  title={Neurofibromin Regulates Seizure Attacks in the Rat Pilocarpine-Induced Model of Epilepsy},
  author={Min Ren and Kun-yi Li and Dajuan Wang and Jiamei Guo and Juan Li and Guang Yang and Xianghua Long and Wenjing Shen and Rong Hu and Xinglong Wang and Kebin Zeng},
  journal={Molecular Neurobiology},
  year={2015},
  volume={53},
  pages={6069-6077}
}
  • Min Ren, Kun-yi Li, +8 authors Kebin Zeng
  • Published in Molecular Neurobiology 2015
  • Medicine
  • Studies have shown that neurofibromin (NF1) restricts GABA release at inhibitory synapses and regulates dendritic spine formation, which may play an important role in temporal lobe epilepsy (TLE). NF1 expression was detected by double-label immunofluorescence, immunohistochemistry, and western blot analysis in the brains of pilocarpine-induced epilepsy model rats at 6 h, 24 h, 72 h, 7 days, 14 days, 30 days, and 60 days after kindling. NF1 was localized primarily in the nucleus and cytoplasm of… CONTINUE READING

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