Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.

@article{Sangha2008Neurofibromin1,
  title={Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.},
  author={Navneet Sangha and Rong Y Wu and Rork Kuick and Scott Powers and David Mu and Diane Fiander and Kit Man Yuen and Hidetaka Katabuchi and Hironori Tashiro and Eric R. Fearon and Kathleen R. Cho},
  journal={Neoplasia},
  year={2008},
  volume={10 12},
  pages={1362-72, following 1372}
}
Ovarian serous carcinoma (OSC) is the most common and lethal histologic type of ovarian epithelial malignancy. Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified. Using a genome-wide screen of DNA copy number alterations in 36 primary OSCs, we identified two tumors with apparent… CONTINUE READING
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