Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development.

@article{Daston1992NeurofibrominAP,
  title={Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development.},
  author={Maryellen M. Daston and Nancy C. Ratner},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1992},
  volume={195 3},
  pages={
          216-26
        }
}
The onset of manifestations of the common, autosomal dominantly inherited disease type 1 neurofibromatosis (NF1) is usually in childhood. To begin to understand the pathogenesis of NF1, we analyzed the developmental pattern of expression of the protein product of the NF1 gene, neurofibromin, by Western blotting and immunohistochemistry using the rat as a model system. Neurofibromin is uniformly distributed throughout embryonic day 10 and 12 rat embryos. By embryonic day 16, neurofibromin… CONTINUE READING
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