Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer.

@article{Rad2016NeurofibromatosisT1,
  title={Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer.},
  author={Ellie Rad and Andrew R Tee},
  journal={Seminars in cell & developmental biology},
  year={2016},
  volume={52},
  pages={39-46}
}
Neurofibromatosis type 1 (NF1) is an autosomal dominant tumour predisposition syndrome that is caused through loss of function mutations of a tumour suppressor gene called Neurofibromin 1. Therapeutic options are currently limited for NF1-associated tumours, where treatment is often restricted to complete surgical resection with clear margins. Herein, we discuss the multifunctional tumour suppressive role of neurofibromin, which is classically known as a GTPase activating protein (GAP) towards… CONTINUE READING
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