Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L.

@article{Rong2004Neurofibromatosis2,
  title={Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L.},
  author={Rong Rong and Xiaoling Tang and David H Gutmann and Keqiang Ye},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 52},
  pages={18200-5}
}
Neurofibromatosis 2 (NF2) is a tumor suppressor, although the molecular mechanism accounting for this effect remains unknown. Here, we show that merlin exerts its activity by inhibiting phosphatidylinositol 3-kinase (PI3-kinase), through binding to PIKE-L. Wild-type merlin, but not patient-derived mutant (L64P), binds PIKE-L and inhibits PI3-kinase activity… CONTINUE READING