Neurofibromatosis 2: clinical and DNA linkage studies of a large kindred.

  title={Neurofibromatosis 2: clinical and DNA linkage studies of a large kindred.},
  author={W. Wertelecki and Guy Rouleau and Duane W. Superneau and L W Forehand and John Michael Williams and Jonathan L. Haines and James F. Gusella},
  journal={The New England journal of medicine},
  volume={319 5},
At least eight provisional categories of neurofibromatosis have been proposed. Among these, neurofibromatosis 1 (von Recklinghausen's disease or peripheral neurofibromatosis) and neurofibromatosis 2 (central or bilateral acoustic neurofibromatosis) have been established as distinct disorders. We studied 15 affected male and 8 affected female members of one large kindred with neurofibromatosis 2. None of the patients met the diagnostic criteria for neurofibromatosis 1. Between the ages of 15 and… CONTINUE READING