Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes.

@article{Bajenaru2001Neurofibromatosis1,
  title={Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes.},
  author={Michaela Livia Bajenaru and Jessica Donahoe and Teresa Corral and Karlyne M. Reilly and Sarah Brophy and Angel Pellicer and David H Gutmann},
  journal={Glia},
  year={2001},
  volume={33 4},
  pages={314-23}
}
Individuals with neurofibromatosis 1 (NF1) develop low-grade astrocytomas at an increased frequency. To gain insight into the function of the Nf1 gene product as a growth regulator for astrocytes, we examined mice heterozygous for a targeted Nf1 mutation. In our previous studies, we demonstrated increased numbers of proliferating astrocytes in Nf1 heterozygote (Nf1+/-) mice in vivo. We now show that cultured Nf1+/- astrocytes exhibit a cell-autonomous growth advantage in vitro associated with… CONTINUE READING

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