Neurofibromas in NF1: Schwann cell origin and role of tumor environment.

@article{Zhu2002NeurofibromasIN,
  title={Neurofibromas in NF1: Schwann cell origin and role of tumor environment.},
  author={Yuan Zhu and Pritam Ghosh and Patrick Charnay and Dennis K. Burns and Luis F Parada},
  journal={Science},
  year={2002},
  volume={296 5569},
  pages={
          920-2
        }
}
Neurofibromatosis type 1 (NF1) is one of the most prevalent dominantly inherited genetic diseases of the nervous system. NF1 encodes a tumor suppressor whose functional loss results in the development of benign neurofibromas that can progress to malignancy. Neurofibromas are complex tumors composed of axonal processes, Schwann cells, fibroblasts, perineurial cells, and mast cells. Through use of a conditional (cre/lox) allele, we show that loss of NF1 in the Schwann cell lineage is sufficient… CONTINUE READING

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