Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function.

@article{Bennett2004NeurofibrillaryTM,
  title={Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function.},
  author={David A. Bennett and Julie A Schneider and Robert Smith Wilson and Julia L. Bienias and Steven E Arnold},
  journal={Archives of neurology},
  year={2004},
  volume={61 3},
  pages={378-84}
}
OBJECTIVE To test the hypothesis that the association of amyloid load with clinical Alzheimer disease (AD) and cognitive impairment is mediated through neurofibrillary tangles. DESIGN Longitudinal clinicopathologic cohort study. PARTICIPANTS AND SETTING Forty-four individuals with clinically diagnosed AD and 53 without dementia who participated in the Religious Orders Study underwent a uniform structured clinical evaluation for AD and cognitive testing about 8 months prior to death, and… CONTINUE READING

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Amyloid, PHF-tau, ubiquitin and synaptic markers in the progression of Alzheimer’s disease: immunocytochemical analyses of frontal cortex from prospectively studied elderly humans

  • DS Wang, E Cochran, DA Bennett, E Mufson, C Eckman, DW. Dickson
  • (REPRINTED) ARCH NEUROL /
  • 2004

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