Neurofibrillary tangles in progressive supranuclear palsy brains exhibit immunoreactivity to frameshift mutant ubiquitin-B protein.

@article{Fergusson2000NeurofibrillaryTI,
  title={Neurofibrillary tangles in progressive supranuclear palsy brains exhibit immunoreactivity to frameshift mutant ubiquitin-B protein.},
  author={Jean Fergusson and M. Landon and James Lowe and Lynley Ward and Fred van Leeuwen and Ruth J. Mayer},
  journal={Neuroscience letters},
  year={2000},
  volume={279 2},
  pages={69-72}
}
In Alzheimer's disease (AD) neurofibrillary tangles (NFT) are strongly tau and ubiquitin immunopositive, and contain an aberrant form of ubiquitin derived from the ubiquitin-B gene denoted as UBB+1. We explored whether the tau-related NFT seen in another neurodegenerative disease, progressive supranuclear palsy (PSP), also showed an accumulation of UBB+1. Three cases of PSP were examined immunohistochemically for tau protein, ubiquitin-protein conjugates and UBB+1 using single and double… CONTINUE READING

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