Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.

@article{Bancher1987NeurofibrillaryTI,
  title={Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.},
  author={Christian Bancher and Hans Lassmann and H Budka and Inge Grundke-Iqbal and Khalid Iqbal and Gerhard Wiche and Franz Seitelberger and Henryk M. Wiśniewski},
  journal={Acta neuropathologica},
  year={1987},
  volume={74 1},
  pages={39-46}
}
The antigenic profile of neurofibrillary tangles (NFT) in Alzheimer's disease (AD), senile dementia of Alzheimer type (SDAT), progressive supranuclear palsy (PSP) and in non-demented aged humans was investigated by light and electron microscopic immunocytochemistry using antisera and monoclonal antibodies to tubulin, microtubule-associated proteins (MAP1, MAP2 and tau), neurofilament proteins and determinants unique to Alzheimer paired helical filaments (PHF). Antibodies to tau proteins labeled… CONTINUE READING