Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease

@article{Jellinger2006NeurofibrillaryTD,
  title={Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease},
  author={Kurt A. Jellinger and Johannes Attems},
  journal={Acta Neuropathologica},
  year={2006},
  volume={113},
  pages={107-117}
}
Neurofibrillary tangle predominant dementia (NFTPD) is a subset of late onset dementia, clinically different from traditional “plaque and tangle” Alzheimer disease (AD): later onset, shorter duration, less severe cognitive impairment, and almost absence of ApoE ε4. Neuropathology reveals abundant allocortical neurofibrillary pathology with no or few isocortical tau lesions, absence of neuritic plaques, absence or scarcity of amyloid deposits, but neurofibrillary changes comprising both 3 and 4… 
Commentary on the Paper "PART, a Distinct Tauopathy, Different from Classical Sporadic Alzheimer Disease"
TLDR
NFTs in the absence of Aβ pathology are also common in cognitively intact elderly individuals, while some ApoE ε4 non-carriers with mild to moderate dementia may have extensive NFT pathology and minimal Aβ plaques.
Neuropathologically defined subtypes of Alzheimer’s disease differ significantly from neurofibrillary tangle-predominant dementia
TLDR
While it shares clinical similarities with regard to female sex predominance, onset in advanced age, and a slow cognitive decline, NFTD has significant pathologic differences from LP AD, suggesting that it may not merely be a variant of AD.
Complex tauopathies versus tangle predominant dementia
TLDR
It should be mentioned that many of the tangles in NFTD are extracellular ‘‘ghost’’ tangles, preferentially being immunoreactive for 3R tau, while intracellular tangles have a mixture of 3R and 4R t Tau, and ‘'pretangles'’ particularly occurring in limbic areas show 4RTau immunoreactivity.
Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease.
TLDR
Evaluated asymmetry of neurofibrillary degeneration between left and right hippocampi in primary age-related tauopathy cases showed the importance of analyzing bilateral hippocampusi in the diagnostic evaluation of PART and potentially of other neurodegenerative diseases.
Primary age-related tauopathy (PART): a common pathology associated with human aging
TLDR
A new term is recommended, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time.
Primary Age-Related Tauopathy (PART): Addressing the Spectrum of Neuronal Tauopathic Changes in the Aging Brain
TLDR
Biomarker and ligand-based radiologic studies will be important to define PART antemortem and prospectively follow its natural history as it remains unclear whether PART is a distinct tauopathic entity separate from AD or rather represents an earlier histologic stage of AD.
Pathobiological Subtypes of Alzheimer Disease
  • K. Jellinger
  • Biology, Psychology
    Dementia and Geriatric Cognitive Disorders
  • 2020
TLDR
Unraveling the heterogeneity among the AD spectrum entities is important for opening a window to pathogenic mechanisms affecting the brain and enabling precision medicine approaches as a basis for developing preventive and ultimately successful disease-modifying therapies for AD.
Neuropathology of the Alzheimer's continuum: an update
TLDR
An up-to-date overview of AD neuropathology, its heterogeneity, and additional pathologies are provided in order to explain the difficulties in the diagnosis and the failure of clinical trials in AD patients.
The enigma of mixed dementia
Absence of α-synuclein pathology in postencephalitic parkinsonism
TLDR
Neuropathologic examination of 10 brains with clinico-pathologically verified PEP confirmed widespread neurodegeneration in subcortical and brainstem areas associated with multifocal neurofibrillary pathology comprising both 3R and 4R tau.
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