Neurofibrillary changes in the cerebral cortex of a patient with subacute sclerosing panencephalitis (SSPE)

@article{PaulaBarbosa2004NeurofibrillaryCI,
  title={Neurofibrillary changes in the cerebral cortex of a patient with subacute sclerosing panencephalitis (SSPE)},
  author={M. Paula-Barbosa and R. Brito and C. A. Silva and R. Faria and C. Cruz},
  journal={Acta Neuropathologica},
  year={2004},
  volume={48},
  pages={157-160}
}
SummaryBiopsy fragments from the frontal cortex of one patient with SSPE were studied with ultrastructural methods. Special attention was given to the presence of neurofibrillary tangles observed in all cortical layers. These tangles were composed either of filaments with a diameter of 10–12 nm or of paired helical filaments 22–24 nm at their widest and periodically reduced to 10 nm about every 80 nm. These tangles were observed in all cortical layers, while those formed by single filaments… Expand
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Biopsy fragments from the frontal cortex of two patients with early forms of subacute sclerosing panencephalitis were studied with ultrastructural methods, finding mitochondrial abnormalities observed in dendrites from the three superficial cortical layers to be precursors of dendritic changes. Expand
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Overall, the distribution of AT resembled that seen in Alzheimer's disease and aging; however, the senile plaques, vascular amyloidosis and granulovacuolar change were totally absent in both cases. Expand
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Golgi studies of three cortical biopsies from patients with SSPE reveal an abnormal pyramidal dendritic domain spine-loss, and reactive gliosis, in keeping with the pathological features observed in other situations in which mental changes occur. Expand
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The present findings indicate that astrocytic and neuronal tau lesions appear in the affected cervical cord during the disease process of CSM. Expand
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It is hypothesize that it is chronic infection of human neurons in Alzheimer's disease that produces neurofibrillary tangles by a pathway similar to the chronic SSPE infection tangle pathway. Expand
Brains With Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct From Alzheimer Disease
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Some of the main animal models that exist for reproducing symptoms of the disorder and their advantages and shortcomings as suitable models of the pathological processes are presented. Expand
Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy
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A complex but enlightening paradigm has emerged, wherein both Tau and TDP-43 proteinopathies are linked to numerous overlapping upstream influences, and both are associated with multiple downstream pathologically- and clinically-defined deleterious effects. Expand
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Parts of amygdalar anatomy, connectivity, vasculature, and pathologic involvement in neurodegenerative diseases with supporting data from the University of Kentucky Alzheimer's Disease Center autopsy cohort are reviewed. Expand

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