Neurofibrillary changes in the cerebral cortex of a patient with subacute sclerosing panencephalitis (SSPE)

@article{PaulaBarbosa2004NeurofibrillaryCI,
  title={Neurofibrillary changes in the cerebral cortex of a patient with subacute sclerosing panencephalitis (SSPE)},
  author={Manuel Maria Paula-Barbosa and Raquel C{\'a}rdenes Brito and C. A. Silva and R. Faria and Celso Cruz},
  journal={Acta Neuropathologica},
  year={2004},
  volume={48},
  pages={157-160}
}
SummaryBiopsy fragments from the frontal cortex of one patient with SSPE were studied with ultrastructural methods. Special attention was given to the presence of neurofibrillary tangles observed in all cortical layers. These tangles were composed either of filaments with a diameter of 10–12 nm or of paired helical filaments 22–24 nm at their widest and periodically reduced to 10 nm about every 80 nm. These tangles were observed in all cortical layers, while those formed by single filaments… 
View on Springer
ncbi.nlm.nih.gov
10 Citations
Background Citations
4
Results Citations
1

10 Citations

Mitochondrial abnormalities in cortical dendrites from patients with early forms of subacute sclerosing panencephalitis (SSPE)
TLDR
Biopsy fragments from the frontal cortex of two patients with early forms of subacute sclerosing panencephalitis were studied with ultrastructural methods, finding mitochondrial abnormalities observed in dendrites from the three superficial cortical layers to be precursors of dendritic changes.
The distribution of Alzheimer's neurofibrillary tangles and gliosis in chronic subacute sclerosing panencephalitis
TLDR
Overall, the distribution of AT resembled that seen in Alzheimer's disease and aging; however, the senile plaques, vascular amyloidosis and granulovacuolar change were totally absent in both cases.
Dendritic abnormalities in patients with subacute sclerosing panencephalitis (SSPE)
TLDR
Golgi studies of three cortical biopsies from patients with SSPE reveal an abnormal pyramidal dendritic domain spine-loss, and reactive gliosis, in keeping with the pathological features observed in other situations in which mental changes occur.
Spinal cord tau pathology in cervical spondylotic myelopathy
TLDR
The present findings indicate that astrocytic and neuronal tau lesions appear in the affected cervical cord during the disease process of CSM.
Alzheimer's neuroborreliosis with trans-synaptic spread of infection and neurofibrillary tangles derived from intraneuronal spirochetes.
Brains With Medial Temporal Lobe Neurofibrillary Tangles But No Neuritic Amyloid Plaques Are a Diagnostic Dilemma But May Have Pathogenetic Aspects Distinct From Alzheimer Disease
TLDR
It is concluded that NFT+/NP− cases comprise approximately 5% of aged individuals in multiple data sets; these cases are not necessarily within the spectrum of AD.
Neuronal Models for Studying Tau Pathology
TLDR
Some of the main animal models that exist for reproducing symptoms of the disorder and their advantages and shortcomings as suitable models of the pathological processes are presented.
Classification of diseases with accumulation of Tau protein
TLDR
In the view, cases with mutations in MAPT are the only known example of a primary tauopathy, whereas familial Alzheimer’s disease may be secondary tauopathies, although these terms should not be used when referring to diseases of unknown aetiology.
Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy
TLDR
A complex but enlightening paradigm has emerged, wherein both Tau and TDP-43 proteinopathies are linked to numerous overlapping upstream influences, and both are associated with multiple downstream pathologically- and clinically-defined deleterious effects.
The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases
TLDR
Parts of amygdalar anatomy, connectivity, vasculature, and pathologic involvement in neurodegenerative diseases with supporting data from the University of Kentucky Alzheimer's Disease Center autopsy cohort are reviewed.

References

SHOWING 1-10 OF 32 REFERENCES
Cerebral cortex denchitic degeneration in subacute sclerosing panencephalitis (SSPE)
TLDR
Electron-dense degenerating dendrites were observed in all cortical layers, more abundantly in layers I, II, and III, and they may be related to the mental changes seen in SSPE.
Alzheimer neurofibrillary change in subacute sclerosing panencephalitis
Abundant instances of Alzheimer neurofibrillary change (ANC) composed of tubules 200 nm wide and twisted into segments each 800 nm in length, indistinguishable from those of Alzheimer disease, were…
Frequency of Alzheimer's neurofibrillary tangles in the cerebral cortex in progressive supranuclear palsy (subcortical argyrophilic dystrophy)
Ultrastructure of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome.
The fine structure of neurofibrillary tangles found in the subthalamic bodies and substantia nigra of postmortem brain in one case of Steele-Richardson-Olszewski syndrome was studied with the…
EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION: 1. LIGHT MICROSCOPIC OBSERVATIONS
TLDR
The effect of alum phosphate which is described may provide an experimental model for further investigations of the morphological substrate of epileptic neuronal activity, as well as of the pathomechanism of neurofibrillary degeneration.
Neurofibrillary changes following childhood lead encephalopathy.
TLDR
The brain revealed diffuse cortical atrophy, most severe in the temporal lobes, followed by hippocampi, amygdaloid nuclei and frontal cortex, and Numerous pyramidal cells of the forebrain grisea contained Alzheimer's neurofibrillary tangles.
Electron microscopic structure of the alzheimer's neurofibrillary changes in case of atypical senile dementia
TLDR
The postmortem examination revealed macroscopically and light microscopically the neuropathological findings of atypical senile dementia and it is the interesting characteristic in the presented case that there are electron microscopical two types of filaments making the neurofibrillary tangles.
Neurofibrillary pathology: Current status and research perspectives
Neurofibrillary tangles of paired helical filaments
EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION: 2. ELECTRON MICROSCOPY, PHOSPHATASE HISTOCHEMISTRY AND ELECTRON PROSE ANALYSIS
  • R. Terry, C. Peña
  • Biology
    Journal of neuropathology and experimental neurology
  • 1965
TLDR
Electron microscopy has demonstrated the fibrillar content of the neuronal lesions in rabbits treated with alum phosphate, and filaments involved in these Alzheimer-like tangles are similar to the filaments found in the human disease.
...
...