Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg.

@article{Querol2014NeurofascinIA,
  title={Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg.},
  author={Luis Antonio Querol and Gisela Nogales-Gadea and Ricard Rojas-Garcia and Jordi D{\'i}az-Manera and J. L. {\'A}lvarez Pardo and Angel Ortega-Moreno and Mar{\'i}a Jos{\'e} Sedano and Eduard Gallardo and Jos{\'e} Berciano and Rafael Blesa and J. L. Dalmau and Isabel Illa},
  journal={Neurology},
  year={2014},
  volume={82 10},
  pages={879-86}
}
OBJECTIVE To describe the frequency of antibodies against neurofascin in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and the associated clinical features. METHODS Immunocytochemistry was used to identify antibodies to neurofascin 155 (NF155) and 186. Serum reactivity with paranodes and brain tissue was tested with immunohistochemistry of teased-nerve fibers and rat brain. Antibody titers and immunoglobulin (Ig) G isotypes were determined using ELISA. Clinical information… CONTINUE READING
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