Neuroexcitatory actions of Tamiflu and its carboxylate metabolite

@article{Izumi2007NeuroexcitatoryAO,
  title={Neuroexcitatory actions of Tamiflu and its carboxylate metabolite},
  author={Yukitoshi Izumi and Kazuhiro Tokuda and Kazuko A. O’Dell and Charles F Zorumski and Toshio Narahashi},
  journal={Neuroscience Letters},
  year={2007},
  volume={426},
  pages={54-58}
}
Oseltamivir (Tamiflu) is now being stockpiled by several governments as a first line treatment for an anticipated outbreak of avian influenza caused by H5N1. However, abnormal behaviors and death associated with the use of Tamiflu have developed into a major issue in Japan where Tamiflu is often prescribed for seasonal influenza. Thus, it is critical to determine neuropsychiatric effects of oseltamivir and to establish methods for safe administration. Using juvenile rats and rat hippocampal… CONTINUE READING

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