Neuroestradiol in the Stalk Median Eminence of Female Rhesus Macaques Decreases in Association With Puberty Onset.

@article{Kenealy2016NeuroestradiolIT,
  title={Neuroestradiol in the Stalk Median Eminence of Female Rhesus Macaques Decreases in Association With Puberty Onset.},
  author={Brian P. Kenealy and Kim L. Keen and Amita Kapoor and Ei Terasawa},
  journal={Endocrinology},
  year={2016},
  volume={157 1},
  pages={70-6}
}
In primates, despite the fact that GnRH neurons are mature at birth, a gonadal steroid independent central inhibition restrains the initiation of puberty. The neural substrates responsible for this central inhibition, however, are unclear. In this study, we tested the hypothesis that neuroestradiol release in the hypothalamus decreases prior to the pubertal increase in GnRH release. We found that in female monkeys at the prepubertal stage, when GnRH release was low, estradiol (E2) levels in the… CONTINUE READING
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