Neuroestradiol in regulation of GnRH release.

  title={Neuroestradiol in regulation of GnRH release.},
  author={Ei Terasawa},
  journal={Hormones and behavior},
The concept that the positive feedback effect of ovarian estradiol (E2) results in GnRH and gonadotropin surges is a well-established principle. However, a series of studies investigating the rapid action of E2 in female rhesus monkeys has led to a new concept that neuroestradiol, synthesized and released in the hypothalamus, also contributes to regulation… CONTINUE READING