Neuroepithelial Stem Cell Proliferation Requires LIS1 for Precise Spindle Orientation and Symmetric Division

@article{Yingling2008NeuroepithelialSC,
  title={Neuroepithelial Stem Cell Proliferation Requires LIS1 for Precise Spindle Orientation and Symmetric Division},
  author={Jessica Yingling and Yong Ha Youn and D. A. Darling and Kazuhito Toyo-oka and Tiziano Pramparo and Shinji Hirotsune and Anthony Wynshaw-Boris},
  journal={Cell},
  year={2008},
  volume={132},
  pages={474-486}
}
Mitotic spindle orientation and plane of cleavage in mammals is a determinant of whether division yields progenitor expansion and/or birth of new neurons during radial glial progenitor cell (RGPC) neurogenesis, but its role earlier in neuroepithelial stem cells is poorly understood. Here we report that Lis1 is essential for precise control of mitotic spindle orientation in both neuroepithelial stem cells and radial glial progenitor cells. Controlled gene deletion of Lis1 in vivo in… CONTINUE READING
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