Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis.

@article{Macrez2016NeuroendothelialNR,
  title={Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis.},
  author={Richard Macrez and Mar{\'i}a Cristina Ortega and Isabelle Bardou and Anupriya Mehra and Antoine Philippe Fournier and Susanne M. A. van der Pol and Benoit Haelewyn and Eric Maubert and Flavie Lesept and Arnaud Chevilley and Fernando de Castro and Helga E. de Vries and Denis Vivien and Diego Clemente and Fabian Docagne},
  journal={Brain : a journal of neurology},
  year={2016},
  volume={139 Pt 9},
  pages={
          2406-19
        }
}
Multiple sclerosis is among the most common causes of neurological disability in young adults. Here we provide the preclinical proof of concept of the benefit of a novel strategy of treatment for multiple sclerosis targeting neuroendothelial N-methyl-D-aspartate glutamate receptors. We designed a monoclonal antibody against N-methyl-D-aspartate receptors, which targets a regulatory site of the GluN1 subunit of N-methyl-D-aspartate receptor sensitive to the protease tissue plasminogen activator… CONTINUE READING
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