Neuroendocrinology of the skin.

@article{Slominski2000NeuroendocrinologyOT,
  title={Neuroendocrinology of the skin.},
  author={Andrzej T Slominski and Jacobo Wortsman},
  journal={Endocrine reviews},
  year={2000},
  volume={21 5},
  pages={
          457-87
        }
}
The classical observations of the skin as a target for melanotropins have been complemented by the discovery of their actual production at the local level. In fact, all of the elements controlling the activity of the hypothalamus-pituitary-adrenal axis are expressed in the skin including CRH, urocortin, and POMC, with its products ACTH, alpha-MSH, and beta-endorphin. Demonstration of the corresponding receptors in the same cells suggests para- or autocrine mechanisms of action. These findings… CONTINUE READING

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