Neuroendocrinology of the hypothalamo-pituitary-adrenal axis in pregnancy and the puerperium.

@article{Smith1991NeuroendocrinologyOT,
  title={Neuroendocrinology of the hypothalamo-pituitary-adrenal axis in pregnancy and the puerperium.},
  author={Roger Smith and Murray Thomson},
  journal={Bailliere's clinical endocrinology and metabolism},
  year={1991},
  volume={5 1},
  pages={167-86}
}
Plasma cortisol, adrenocorticotrophic hormone (ACTH), beta-endorphin and corticotrophin releasing hormone or factor (CRF) all rise progressively as pregnancy advances, and fall postnatally. The placenta produces large amounts of CRF in the third trimester and this is released into the maternal circulation. Present evidence suggests that it stimulates the maternal pituitary to produce ACTH while desensitizing the maternal pituitary to further stimulation with CRF. Maternal control of ACTH… CONTINUE READING
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