Neuroendocrinological and neurochemical effects of sigma ligands

  title={Neuroendocrinological and neurochemical effects of sigma ligands},
  author={Gary A. Gudelsky and J. Frank Nash},
The potential antipsychotic agents BMY 14802, remoxipride, tiospirone and gevotriline (WY 47,384) have a relatively high affinity for sigma binding sites in brain tissue. In the present study, the effects of these sigma ligands on concentrations of prolactin and corticosterone in serum in the rat were investigated. In addition, the effects of these agents on the synthesis and/or release of dopamine from tuberoinfundibular and nigrostriatal neurons were determined. Concentrations of prolactin… CONTINUE READING