Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro.

@article{Moin2012NeuroendocrineRP,
  title={Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro.},
  author={Abu Saleh Md Moin and Hideki Yamaguchi and Marie Rhee and Ji-Wom Kim and Koji Toshinai and T. M. Zaved Waise and Farhana Naznin and Takashi Matsuo and Kazuki Sasaki and Naoto Minamino and K N Yoon and Masamitsu Nakazato},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={428 4},
  pages={512-7}
}
Neuroendocrine regulatory peptide (NERP)-2, recently identified as a bioactive peptide involved in vasopressin secretion and feeding regulation in the central nervous system, is abundantly expressed in endocrine cells in peripheral tissues. To explore the physiological roles of NERP-2 in the pancreas, we examined its effects on insulin secretion. NERP-2 increased glucose-stimulated insulin secretion (GSIS) in a dose-dependent manner, with a lowest effective dose of 10(-7) M, from the pancreatic… CONTINUE READING

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