Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction.

  title={Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction.},
  author={Carroll and George C. Curtis and Joseph Mendels},
  journal={Archives of general psychiatry},
  volume={33 9},
The regulation of hypothalamopituitary-adrenal (HPA) function in depressed patients was studied by a midnight dexamethasone suppression test. By using an observation period of 24 hours postadministration of dexamethasone, a graded series of abnormal test responses was identified. Depressed patients show abnormal early escape from suppression rather than absolute resistance to HPA suppression by dexamethasone. With increasing severity of depression, this escape occurs progressively more early on… CONTINUE READING


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