Neuroendocrine mechanisms underlying the effects of progesterone on the oestradiol-induced GnRH/LH surge.

Abstract

Oestradiol provides the drive to reproductive cyclicity in female mammals through its ability to stimulate the GnRH surge. In contrast, progesterone can be seen as the 'clutch and brakes' within reproductive cycles, as it can modify the response of the GnRH neurosecretory system to oestradiol. In this regard, progesterone has multiple and sometimes opposing… (More)

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