Neuroendocrine involvement in aging: evidence from studies of reproductive aging and caloric restriction.

@article{Nelson1995NeuroendocrineII,
  title={Neuroendocrine involvement in aging: evidence from studies of reproductive aging and caloric restriction.},
  author={James F. Nelson and K Karelus and M D Bergman and Leda Felicio},
  journal={Neurobiology of aging},
  year={1995},
  volume={16 5},
  pages={837-43; discussion 855-6}
}
Neuroendocrine changes contribute to female reproductive aging, but changes in other tissues also play a role. In C57BL/6J mice, neuroendocrine changes contribute to estrous cycle lengthening and reduced plasma estradiol levels, but the midlife loss of cyclicity is mainly due to ovarian failure. Hypothalamic estrogen receptor dynamics and estrogenic modulation of gene expression are altered in middle-aged cycling mice. Although insufficient to arrest cyclicity, these neuroendocrine changes may… CONTINUE READING
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