Neuroendocrine features of reactive bile ductules in cholestatic liver disease.

@article{Roskams1990NeuroendocrineFO,
  title={Neuroendocrine features of reactive bile ductules in cholestatic liver disease.},
  author={Tania A Roskams and Joost J. van den Oord and R De vos and Valeer Julien Desmet},
  journal={The American journal of pathology},
  year={1990},
  volume={137 5},
  pages={1019-25}
}
Various cholestatic liver diseases are accompanied by a striking increase in the number of bile ductules. This so-called ductular reaction is thought to arise both from ductular metaplasia of hepatocytes and from proliferation of pre-existing bile ductules. Previous studies have shown that these reactive bile ductules differ from their normal counterpart in enzyme and immunohistochemical make-up. Using monoclonal antibodies directed to neuroendocrine markers and immunohistochemistry, we found… CONTINUE READING