Neuroendocrine factors in the initiation of puberty: The emergent role of kisspeptin

  title={Neuroendocrine factors in the initiation of puberty: The emergent role of kisspeptin},
  author={Victor M Navarro and Juan Manuel Castellano and David Garc{\'i}a-Galiano and Manuel Tena-Sempere},
  journal={Reviews in Endocrine and Metabolic Disorders},
Puberty is the end-point of a complex series of developmental events, defined by the dynamic interaction between genetic factors and environmental cues, ultimately leading to the attainment of reproductive capacity. The neuroendocrine basis of puberty has been the subject of extensive investigation in the last decades, and identification of the trigger(s) of puberty onset has drawn considerable attention. In this context, recognition of the fundamental role of kisspeptin (encoded by the KiSS-1… CONTINUE READING

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