Neuroendocrine effects of intravenous clomipramine in depressed patients and healthy subjects.

@article{Golden1992NeuroendocrineEO,
  title={Neuroendocrine effects of intravenous clomipramine in depressed patients and healthy subjects.},
  author={Robert N. Golden and David Ekstrom and Thomas M. Brown and Rachael Ruegg and Dwight L. Evans and Joann Haggerty and James C. Garbutt and Cort A. Pedersen and George A. Mason and Jennifer Browne},
  journal={The American journal of psychiatry},
  year={1992},
  volume={149 9},
  pages={1168-75}
}
OBJECTIVE Neuroendocrine challenge paradigms have been used to asses serotonergic systems in depression, but limitations in the specificity of many of these tests have been noted. In this study, the neuroendocrine responses to acute intravenous administration of the serotonin (5-HT) reuptake inhibitor clomipramine were assessed in depressed patients and matched control subjects. METHODS Thirty hospitalized patients who met DSM-III-R criteria for major depression, and 30 healthy control… CONTINUE READING

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