Neuroendocrine differentiation is a relevant prognostic factor in stage III-IV colorectal cancer.

  title={Neuroendocrine differentiation is a relevant prognostic factor in stage III-IV colorectal cancer.},
  author={Patricia Grabowski and Isabell Schindler and Ioannis Anagnostopoulos and Hanne Foss and Ernst Otto Riecken and Ulrich Mansmann and Harald Von Stein and Gerd Berger and Heinz Johannes Buhr and Hans Scher{\"u}bl},
  journal={European journal of gastroenterology & hepatology},
  volume={13 4},
OBJECTIVE To determine the prognostic relevance of neuroendocrine differentiation in colorectal cancer. METHODS The survival of 116 patients with colorectal cancer of stages III (n = 59) and IV (n = 57) was correlated with the extent of neuroendocrine differentiation. Chromogranin A and synaptophysin were used as neuroendocrine markers. Based on the degree of immunoreactivity for these markers, tumours were classified as 0 (no expression of neuroendocrine markers), 1 (< 2% cells staining… CONTINUE READING
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