which is present in the normal, hyperplastic and dysplastic prostate. NE cells are located in all regions of the human prostate at birth, but rapidly decrease in the peripheral prostate after birth and then reappear at puberty . After puberty, the number of NE cells seems to increase until an apparently optimum level is reached, which persists from 25 to 54 years old . The relationship of age beyond puberty to the number and distribution of these endocrine-paracrine cells has not been definitively assessed, but in the guinea pig these cells in the peripheral prostate increase markedly with adult age . Studies on adult human prostates indicate that NE cells are more frequent in the periurethral ducts than in the peripheral parts of the gland . Others [8,9] also described the presence of NE cells in the stroma of fetal and infantile prostates.