Neuroendocrine differentiation correlates with hormone receptor expression and decreased survival in patients with invasive breast carcinoma.

@article{Kwon2014NeuroendocrineDC,
  title={Neuroendocrine differentiation correlates with hormone receptor expression and decreased survival in patients with invasive breast carcinoma.},
  author={Sun Young Kwon and Young Kyung Bae and Mi Gu and Jung Eun Choi and Su Hwan Kang and Soo Jung Lee and Aeri C Kim and Hye Ra Jung and Sun Hee Kang and Hoon Oh and Ji Young Park},
  journal={Histopathology},
  year={2014},
  volume={64 5},
  pages={647-59}
}
AIMS Invasive breast carcinoma (IBC) with neuroendocrine (NE) differentiation has been controversial in terms of its definition and clinical outcome. We investigated the incidence and clinical significance of NE differentiation in patients with IBC. METHODS AND RESULTS We performed immunohistochemistry for NE markers, chromogranin-A and synaptophysin on 1428 IBC samples using tissue microarrays and classified cases with NE differentiation into two groups, focal (1-49% tumour cells positive… CONTINUE READING
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