Neuroendocrine-derived peptides promote prostate cancer cell survival through activation of IGF-1R signaling.

@article{Dasilva2013NeuroendocrinederivedPP,
  title={Neuroendocrine-derived peptides promote prostate cancer cell survival through activation of IGF-1R signaling.},
  author={John O Dasilva and George P. Amorino and Eli V. Casarez and Bradley Pemberton and Sarah J Parsons},
  journal={The Prostate},
  year={2013},
  volume={73 8},
  pages={801-12}
}
BACKGROUND Neuroendocrine (NE) cells promote the progression of prostate cancer to a castration-resistant state through the production of paracrine growth factors. We have demonstrated this principle using in vitro and in vivo proliferative endpoints; however, the contributions of NE-derived pro-survival factors and anti-apoptosis to this phenomenon have not been thoroughly investigated. METHODS Here, we utilized conditioned-medium (CM) from LNCaP cells, engineered to undergo NE… CONTINUE READING
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