Neuroendocrine Regulation of GnRH Release in Induced Ovulators

  title={Neuroendocrine Regulation of GnRH Release in Induced Ovulators},
  author={Julie Bakker and Michael J Baum},
  journal={Frontiers in Neuroendocrinology},
GnRH is the key neuropeptide controlling reproductive function in all vertebrate species. Two different neuroendocrine mechanisms have evolved among female mammals to regulate the mediobasal hypothalamic (MBH) release of GnRH leading to the preovulatory secretion of LH by the anterior pituitary gland. In females of spontaneously ovulating species, including rats, mice, guinea pigs, sheep, monkeys, and women, ovarian steroids secreted by maturing ovarian follicles induce a pulsatile pattern of… 

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