Neuroendocrine Evidence That (S)-2-(Chloro-5-fluoro-indol- l-yl)-1-methylethylamine Fumarate (Ro 60-0175) Is Not a Selective 5-Hydroxytryptamine2C Receptor Agonist

  title={Neuroendocrine Evidence That (S)-2-(Chloro-5-fluoro-indol- l-yl)-1-methylethylamine Fumarate (Ro 60-0175) Is Not a Selective 5-Hydroxytryptamine2C Receptor Agonist},
  author={Katerina J. Damjanoska and Nancy A. Muma and Y. Zhang and Deborah N D'souza and F. Garc{\'i}a and Gonzalo A. Carrasco and Gisela Kindel and Kristi Haskins and Mahalakshmi Shankaran and B. R. Petersen and Louis D. van de Kar},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={1209 - 1216}
The 5-hydroxytryptamine2A and 2C(5-HT2A and 5-HT2C) receptors are so closely related that selective agonists have not been developed until recently with the advent of (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175), a putatively selective 5-HT2Creceptor agonist. In the present study, Ro 60-0175 was used to analyze the importance of 5-HT2C receptors in hormone secretion. Injection of Ro 60-0175 (5 mg/kg s.c.) produced a maximum increase in plasma levels of… 

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