Neuroendocrine Differentiation in Prostate Cancer: A Mechanism of Radioresistance and Treatment Failure

@inproceedings{Hu2015NeuroendocrineDI,
  title={Neuroendocrine Differentiation in Prostate Cancer: A Mechanism of Radioresistance and Treatment Failure},
  author={C H Hu and Richard C. Choo and Jiaoti Huang},
  booktitle={Front. Oncol.},
  year={2015}
}
Neuroendocrine differentiation (NED) in prostate cancer is a well-recognized phenotypic change by which prostate cancer cells transdifferentiate into neuroendocrine-like (NE-like) cells. NE-like cells lack the expression of androgen receptor and prostate specific antigen, and are resistant to treatments. In addition, NE-like cells secrete peptide hormones and growth factors to support the growth of surrounding tumor cells in a paracrine manner. Accumulated evidence has suggested that NED is… CONTINUE READING
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