Neurodevelopmental implications of the use of sedation and analgesia in neonates.

@article{Davidson2013NeurodevelopmentalIO,
  title={Neurodevelopmental implications of the use of sedation and analgesia in neonates.},
  author={Andrew J Davidson and Randall P. Flick},
  journal={Clinics in perinatology},
  year={2013},
  volume={40 3},
  pages={559-73}
}
Laboratory studies have shown that general anesthetics may cause accelerated apoptosis and other adverse morphologic changes in neurons of the developing brain. The mechanism may be related to the neuronal quiescence or inactivity associated with anesthetic exposure. Few data exist on how brief anesthetic exposure may affect neurodevelopment in the newborn. Good evidence however shows that untreated pain and stress have an adverse effect on neurodevelopment, and therefore, at this stage… CONTINUE READING