Neurodevelopmental disorders: Zika virus causes brain defects in mice


Ketamine’s usefulness as an antidepressant is limited by side effects, including abuse potential and sensory dissociation, and its mechanism of action remains unclear. Here, the authors show that ketamine mediates its antidepressant activity not through NMDA receptor inhibition, as previously assumed, but by boosting AMPA receptor activation. Furthermore, its metabolite (2R,6R)-hydroxynorketamine is shown to have potent and rapid antidepressant activity in mouse models of depression, and to lack ketamine-related side effects, suggesting a new approach to the development of rapidly acting antidepressants.

DOI: 10.1038/nrn.2016.74

Cite this paper

@article{Whalley2016NeurodevelopmentalDZ, title={Neurodevelopmental disorders: Zika virus causes brain defects in mice}, author={Katherine M. Whalley}, journal={Nature Reviews Neuroscience}, year={2016}, volume={17}, pages={399-399} }