Neurodevelopmental control by thyroid hormone receptors

@article{Forrest2002NeurodevelopmentalCB,
  title={Neurodevelopmental control by thyroid hormone receptors},
  author={Douglas Forrest and Thomas A. Reh and Alfons Rüsch},
  journal={Current Opinion in Neurobiology},
  year={2002},
  volume={12},
  pages={49-56}
}
Expression of Thyroid Hormone Receptor Isoforms in the Oligodendrocyte Lineage
TLDR
Re-expression of TRs and also that of other transcription factors in oligodendrocytes may constitute some of the metabolic changes required for succesful remyelination in the adult central nervous system after demyelinating lesions.
Thyroid Hormone Actions on Neural Cells
TLDR
Interestingly, in addition to these direct actions on neuronal and glial cells, several lines of evidence, notably developped in the laboratory, point out the role of thyroid hormone in neuronal–glial interactions.
Tissues Specific Action of Thyroid Hormones: Insights from Knock out Animal Models
TLDR
The ability to create targeted mutations in specific genes in the mouse has allowed to generate relevant mouse models in which either the production of thyroid hormones or the function of thyroid hormone receptors (TRs) and related products is defective.
Thyroid hormone receptors in health and disease.
TLDR
Mutations in both the THRA and THRB gene have been described, each inducing a characteristic phenotype clearly showing the selective effect of an excess or shortage of thyroid hormone in specific TRα and TRβ regulated organs.
The importance of thyroid hormone transporters for brain development and function.
  • H. Heuer
  • Biology, Medicine
    Best practice & research. Clinical endocrinology & metabolism
  • 2007
Thyroid hormone receptors: lessons from knockout and knock-in mutant mice
Implications of Thyroid Hormone Signaling Through the Phosphoinositide-3 Kinase for Xenobiotic Disruption of Human Health
TLDR
Inhibition of PI3K activity is predicted to exacerbate several of the fastest growing chronic human health problems in the USA, including early learning difficulties, cardiovascular disease, obesity and diabetes, and neurodegenerative diseases of the aging brain.
Lack of thyroid hormone receptor α1 is associated with selective alterations in behavior and hippocampal circuits
TLDR
It is demonstrated that mice lacking the TRα1 isoform display behavioral abnormalities of hippocampal origin, and the possibility that deletions or mutations of this receptor isoform may lead to behavioral changes or even psychiatric syndromes in humans is raised.
Thyroid Hormone Induces Cerebellar Purkinje Cell Dendritic Development via the Thyroid Hormone Receptor α1
TLDR
Results indicate that T3 directly affects Purkinje cell differentiation through activation of the TRα1, and it is demonstrated for the first time that the effects of T3 acts onPurkinje cells directly through TR α1 expressed on the Purkinjen cell and not on the granule cell, the presynaptic partner of Purkinja cells.
Role and Mechanisms of Actions of Thyroid Hormone on the Skeletal Development
TLDR
Findings are described that suggest that thyroid hormone regulates a number of key growth factor signaling pathways including insulin-like growth factor-I, parathyroid hormone related protein, fibroblast growth factor, Indian hedgehog and Wnt to influence skeletal growth.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
Functions of thyroid hormone receptors in mice.
TLDR
Investigation of the TR pathways underlying many functions of thyroid hormone and the deletion of combinations of TRalpha and TRbeta variants has revealed that additional functions are convergently regulated by both TR genes and indicates that control of an extended range of functions is facilitated by a network of specific and common TR pathways.
An unliganded thyroid hormone receptor causes severe neurological dysfunction
TLDR
These findings demonstrate the specific and deleterious action of unliganded TR in the brain and suggest the importance of corepressors bound toTR in the pathogenesis of hypothyroidism.
Thyroid hormone receptors: multiple forms, multiple possibilities.
  • M. Lazar
  • Biology, Medicine
    Endocrine reviews
  • 1993
TLDR
The specificity of thenuclear T3 receptors for thyroid hormone analogs closely parallels the biological potency of the compounds, and the levels of the nuclear TRs correlate well with the developmental and tissue-specific effects of T3 in most cases.
Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development
TLDR
It is shown by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH), and that redundancy is only partial and concerns a limited number of functions.
Role of thyroid hormone receptors in timing oligodendrocyte differentiation.
TLDR
It is shown here that overexpression of TR beta1 promotes precocious oligodendrocyte differentiation, whereas expression of two dominant-negative forms of TRbeta1 greatly delays differentiation, and that TRalpha2 mRNA, which encodes a dominant- negative form of TRalpha, decreases as OPCs proliferate in vitro and in vivo.
Ligands of steroid/thyroid receptors induce cone photoreceptors in vertebrate retina.
TLDR
It is reported that thyroid hormone induces an increase in the number of cone photoreceptors that develop in embryonic rat retinal cultures, and that different photoreceptor phenotypes may be modulated through the formation of thyroid/retinoid receptor heterodimers.
Molecular basis of thyroid hormone-dependent brain development.
TLDR
The role of maternal thyroid hormone in fetal brain development and regulation of gene expression by T3 through indirect molecular pathways is investigated.
Genetic Analysis Reveals Different Functions for the Products of the Thyroid Hormone Receptor α Locus
TLDR
It is demonstrated that the TRΔα protein isoforms, which are natural products of the TRα locus, are the key determinants of these phenotypical differences.
Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.
TLDR
It is demonstrated that mice lacking both TRalpha1 and TRbeta (TRalpha1(-/-)beta-/-) display a novel array of phenotypes not found in single receptor-deficient mice, including an extremely hyperactive pituitary-thyroid axis, poor female fertility and retarded growth and bone maturation, which suggest that T3-independent actions of T3 receptors, demonstrated previously in vitro, may be a significant function in vivo.
...
1
2
3
4
5
...