Neurodevelopmental and neurodegenerative models of schizophrenia: white matter at the center stage.

  title={Neurodevelopmental and neurodegenerative models of schizophrenia: white matter at the center stage.},
  author={Peter V. Kochunov and L. Elliot Hong},
  journal={Schizophrenia bulletin},
  volume={40 4},
Schizophrenia is a disorder of cerebral disconnectivity whose lifetime course is modeled as both neurodevelopmental and neurodegenerative. The neurodevelopmental models attribute schizophrenia to alterations in the prenatal-to-early adolescent development. The neurodegenerative models identify progressive neurodegeneration as its core attribute. Historically, the physiology, pharmacology, and treatment targets in schizophrenia were conceptualized in terms of neurons, neurotransmitter levels… 

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