Neurodegenerative stimuli induce persistent ADF/cofilin–actin rods that disrupt distal neurite function

@article{Minamide2000NeurodegenerativeSI,
  title={Neurodegenerative stimuli induce persistent ADF/cofilin–actin rods that disrupt distal neurite function},
  author={Laurie S. Minamide and Amanda M. Striegl and Judith A. Boyle and Peter J. Meberg and James R. Bamburg},
  journal={Nature Cell Biology},
  year={2000},
  volume={2},
  pages={628-636}
}
Inclusions containing actin-depolymerizing factor (ADF) and cofilin, abundant proteins in adult human brain, are prominent in hippocampal and cortical neurites of the post-mortem brains of Alzheimer's patients, especially in neurites contacting amyloid deposits. The origin and role of these inclusions in neurodegeneration are, however, unknown. Here we show that mediators of neurodegeneration induce the rapid formation of transient or persistent rod-like inclusions containing ADF/cofilin and… CONTINUE READING
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