Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.

@article{Stewart2005NeurodegenerativeII,
  title={Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.},
  author={Richard S. Stewart and Pedro Piccardo and Bernardino Ghetti and David A Harris},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 13},
  pages={
          3469-77
        }
}
Although PrP(Sc) is thought to be the infectious form of the prion protein, it may not be the form that is responsible for neuronal cell death in prion diseases. (Ctm)PrP is a transmembrane version of the prion protein that has been proposed to be a neurotoxic intermediate underlying prion-induced pathogenesis. To investigate this hypothesis, we have constructed transgenic mice that express L9R-3AV PrP, a mutant prion protein that is synthesized exclusively in the (Ctm)PrP form in transfected… CONTINUE READING
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Prion protein expression in different species: analysis with a panel of new mAbs.

Proceedings of the National Academy of Sciences of the United States of America • 1998
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