Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T.

@article{Kumar2012NeurodegenerativeED,
  title={Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T.},
  author={B S Hemanth Kumar and Sushanta Kumar Mishra and Poonam Rana and Sadhana Singh and Subash Khushu},
  journal={Behavioural brain research},
  year={2012},
  volume={232 1},
  pages={53-9}
}
Depression is a complex psychiatric disorder characterized by anhedonia and feeling of sadness and chronic mild stress (CMS) seems to be a valuable animal model of depression. CMS animal model was induced and validated using behavioral studies. In the present study we investigated the neuro-metabolite changes occurring in prefrontal cortex and hippocampus during the onset of depression, in CMS rat model using in vivo proton magnetic resonance spectroscopy ((1)H MRS) at field strength of 7 T… CONTINUE READING
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