Neurodegenerative disorders with extensive tau pathology: a comparative study and review.

@article{Feany1996NeurodegenerativeDW,
  title={Neurodegenerative disorders with extensive tau pathology: a comparative study and review.},
  author={Mel B. Feany and Dennis W. Dickson},
  journal={Annals of neurology},
  year={1996},
  volume={40 2},
  pages={139-48}
}
Many neurodegenerative disorders with onset in mid to late adult life present diagnostic challenges to clinicians and pathologists alike. A distinguishing neuropathological feature has traditionally been the presence or absence of neurofibrillary tangles. Recent biochemical and molecular biological studies have identified the microtubule-binding protein tau as the predominant component of these and related inclusions, and have provided powerful new reagents for the study of neurodegenerative… CONTINUE READING
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