Neurodegenerative disease and adult neurogenesis

@article{Winner2011NeurodegenerativeDA,
  title={Neurodegenerative disease and adult neurogenesis},
  author={Beate Winner and Zacharias Kohl and Fred H. Gage},
  journal={European Journal of Neuroscience},
  year={2011},
  volume={33}
}
The generation and cell death of newly generated cells have critical roles in brain development and maintenance in the embryonic and adult brain. Alterations in these processes are also seen in neurodegenerative diseases. Genes that are key players in neurodegenerative diseases (α‐synuclein, presenilin‐1, tau, huntingtin) are also physiologically involved in modulating brain plasticity. Interestingly, in some neurodegenerative diseases, the specific alterations in neurogenic areas such as the… 
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References

SHOWING 1-10 OF 159 REFERENCES
Neurogenesis and Alzheimer's disease: At the crossroads
Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease
TLDR
The proliferation and survival of NPC in the dentate gyrus of the hippocampus was reduced in mice transgenic for a mutated form of amyloid precursor protein that causes early onset familial AD.
Neurogenesis and Alzheimer's disease: Biology and pathophysiology in mice and men.
TLDR
The collective literature findings are reviewed, the structural and molecular mechanisms governing adult neurogenesis are important for evaluating therapeutic strategies, and the future of this field is speculated with a focus on findings from Alzheimer's mouse models.
Increased hippocampal neurogenesis in Alzheimer's disease
  • K. Jin, A. Peel, D. Greenberg
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
It is suggested that neurogenesis is increased in AD hippocampus, where it may give rise to cells that replace neurons lost in the disease, and that stimulating hippocampal neuroGenesis might provide a new treatment strategy.
Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis
TLDR
It is suggested that Aβ-associated increases in BMP6 expression in AD may have deleterious effects on neurogenesis in the hippocampus, and therapeutic approaches could focus on normalization of B MP6 levels to protect against AD-related neurogenic deficits.
Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease
TLDR
3xTg-AD mice have an impaired ability to generate new neurones in the DG of the hippocampus, the severity of which increases with age and might be directly associated with the known cognitive impairment observed from 6 months of age onwards.
Abnormalities of Neurogenesis in the R6/2 Mouse Model of Huntington's Disease Are Attributable to the In Vivo Microenvironment
TLDR
The results suggest that abnormal neurogenesis in the R6/2 mouse is not attributable to an intrinsic impairment of the NPC itself but is attributable to the environment in which the cell is located.
Mechanisms and Functional Implications of Adult Neurogenesis
Human Wild‐Type α‐Synuclein Impairs Neurogenesis
TLDR
Examination of regions of neurogenesis in adult mice overexpressing human wild-type α-synuclein under the control of the platelet-derived growth factor promoter suggests that the finely tuned equilibrium of neuronal cell birth and death in neurogenic regions may be altered in human α- synuclein-overexpressing mice.
...
1
2
3
4
5
...