Neurodegeneration in the Niemann–Pick C mouse: glial involvement

@article{German2002NeurodegenerationIT,
  title={Neurodegeneration in the Niemann–Pick C mouse: glial involvement},
  author={Dwight C. German and C. -L Liang and Ting Song and Umar Yazdani and John M. Dietschy},
  journal={Neuroscience},
  year={2002},
  volume={109},
  pages={437-450}
}
A mouse model of Niemann-Pick type C disease has been found that exhibits neuropathology similar to the human condition. There is an age-related neurodegeneration in several brain regions and a lack of myelin in the corpus callosum in these mice. The purpose of the present study was to examine the Niemann-Pick mouse and determine whether: (1) microglia and astrocytes exhibit ultrastructural pathology similar to that found in neurons; (2) nerve fiber number is reduced when the myelin sheath is… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 58 CITATIONS, ESTIMATED 52% COVERAGE

In Vivo Assessment of Neurodegeneration in Type C Niemann-Pick Disease by IDEAL-IQ

  • Korean journal of radiology
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2002
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations