Neurodegeneration in a Drosophila Model for the Function of TMCC2, an Amyloid Protein Precursor-Interacting and Apolipoprotein E-Binding Protein

@inproceedings{Hopkins2013NeurodegenerationIA,
  title={Neurodegeneration in a Drosophila Model for the Function of TMCC2, an Amyloid Protein Precursor-Interacting and Apolipoprotein E-Binding Protein},
  author={Paul C. R. Hopkins},
  booktitle={PloS one},
  year={2013}
}
We previously identified TMCC2 as a protein that interacted differentially with normal versus Alzheimer's disease-risk forms of both apolipoprotein E (apoE) and the amyloid protein precursor (APP). We hypothesized that disrupted function of TMCC2 would affect neurodegeneration. To test this hypothesis, we investigated the Drosophila orthologue of TMCC2, that we have named Dementin. We showed that Dementin interacts genetically both with human APP and its Drosophila orthologue, the APP-like… CONTINUE READING
2
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Metabolic regulation during early embryo development

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Drosophila melanogaster: Deciphering Alzheimer's Disease.

  • The Malaysian journal of medical sciences : MJMS
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2006
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL