Neurodegeneration in Lurcher mice occurs via multiple cell death pathways.

@article{Doughty2000NeurodegenerationIL,
  title={Neurodegeneration in Lurcher mice occurs via multiple cell death pathways.},
  author={Martin L Doughty and Philip L De Jager and S Stanley J. Korsmeyer and Nathaniel Heintz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 10},
  pages={3687-94}
}
Lurcher (Lc) is a gain-of-function mutation in the delta2 glutamate receptor (GRID2) that results in the cell-autonomous death of cerebellar Purkinje cells in heterozygous lurcher (+/Lc) mice. This in turn triggers the massive loss of afferent granule cells during the first few postnatal weeks. Evidence suggests that the death of Purkinje cells as a direct consequence of GRID2(Lc) activation and the secondary death of granule cells because of target deprivation occur by apoptosis. We have used… CONTINUE READING
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