Neurodegeneration in Lurcher mice occurs via multiple cell death pathways.

  title={Neurodegeneration in Lurcher mice occurs via multiple cell death pathways.},
  author={Martin L Doughty and Philip L De Jager and S Stanley J. Korsmeyer and Nathaniel Heintz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={20 10},
Lurcher (Lc) is a gain-of-function mutation in the delta2 glutamate receptor (GRID2) that results in the cell-autonomous death of cerebellar Purkinje cells in heterozygous lurcher (+/Lc) mice. This in turn triggers the massive loss of afferent granule cells during the first few postnatal weeks. Evidence suggests that the death of Purkinje cells as a direct consequence of GRID2(Lc) activation and the secondary death of granule cells because of target deprivation occur by apoptosis. We have used… CONTINUE READING
36 Citations
44 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 36 extracted citations


Publications referenced by this paper.
Showing 1-10 of 44 references

Calcium and excitotoxic neuronal injury

  • SP Cregan, JG MacLaurin, +4 authors RS Slack
  • Ann NY Acad Sci
  • 1999
Highly Influential
4 Excerpts

Cloning and characterization of the lurcher allele of glutamate receptor d2: aberrant activation of a receptor complex results in neuronal death

  • PL De Jager
  • PhD thesis,
  • 1998
Highly Influential
6 Excerpts

The role of free radicals and p53 in neuron apoptosis in vivo

  • KA Woods, RJ Youle
  • J Neurosci
  • 1995
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…